学术预先报告:小分子再生法学药物的发掘到多

作者:威尼斯人科学

告知时间:20一七年3月1日(星期3)一5:00-一7:00

学术预报:化学中的催化,小编的有机化学之路

应自己校生命科学大学邓成人事教育育授和辽宁省生化与分子生物学学会青年委员会的特约,U.S.A.Scripps研商所和北达科他州生物医药研讨所研商员杨鹏宇学士定于2016年7月二1二十八日中午1一点做学术报告。

告知标题:From Molecule to Mammal: Inventing Luminescent Nanoparticles for Biology报 告 人:韩纲 教授(U.S.麻省大学)邀 请 人:秦安军 教师告诉时间:二零一八年三月10日(星期4)清晨1六:00告知地方:5山校区北区发光材料与器件国重50二会议室接待广大师生踊跃加入。材质科学与工程大学二零一八年四月二十六日告诉摘要:Functional luminescent nanoparticles are promising materials for in vitro and in 摩托罗拉 optical imaging and therapy due to their unique optical and chemical properties. In this talk, I will present a series of biocompatible luminescence nanoparticles. The first type of materials is upconversion nanoparticles (UCNPs). I will present new developments regarding engineering UCNPs towards optogenetic applications一 in neuro-engineering and cancer immunotherapy2. The second type of nanoparticles is persistent luminescence nanoparticles (PLNPs).叁 They are bioluminescence-like and possess unprecedented in Nokia deep tissue energy rechargeability, outstanding signal-to-noise-ratio with no need for an excitation resource (light) during imaging, and they can be directly detected with existing imaging systems. These nanoparticles continue to emit light for minutes or hours and, in some cases, days, after turning off the excitation source. These long-lasting, light-emitting nanocrystals can provide noninvasive imaging technology for evaluating structural and functional biological processes in living animals and patients. The third is a type of organic Biodpy nanoparticles that were tailored with outstanding NIRAV4 absorbing ability. Rather than the conventional laser light needed in PDT, I will present their ultralow power lamp operable PDT applications in deep tissue tumor treatment.肆 Finally, I would like also to introduce a new organic upconversion system for in iPhone anticancer release. 5References一. Wu, X.; Zhang, Y.; Takle, K.; Bilsel, O.; Li, Z.; Lee, H.; Zhang, Z.; Li, D.; Fan, W.; Duan, C.; Chan, E. M.; Lois, C.; Xiang, Y.; Han, G., Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano 2016, 十 (1), 十60-陆.二. He, L.; Zhang, Y.; Ma, G.; Tan, P.; Li, Z.; Zang, S.; Wu, X.; Jing, J.; Fang, S.; Zhou, L., Near-infrared photoactivatable control of Ca二 signaling and optogenetic immunomodulation. 埃利fe 20一五, 肆, e1002四.三. (a) Li, Z.; Zhang, Y.; Wu, X.; Maudgal, QX56.; Zhang, H.; Han, G., In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous 三氧化二铝/ZnGa2O4:Cr(三 ) Persistent Luminescence Nanocomposites. Adv Sci (Weinh) 20一五, 2 (3); (b) Li, Z.; Zhang, Y.; Wu, X.; Huang, L.; Li, D.; Fan, W.; Han, G., Direct Aqueous-Phase Synthesis of Sub-10 nm "Luminous Pearls" with Enhanced in Vivo 雷内wable Near-Infrared Persistent Luminescence. J Am Chem Soc 20壹5, 一三七 (1陆), 5304-7.四. (a) Huang, L.; Li, Z.; Zhao, Y.; Zhang, Y.; Wu, S.; Zhao, J.; Han, G., Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy. J Am Chem Soc 201陆, 138 (44), 145八陆-145玖1; (b) Huang, L.; Li, Z.; Zhao, Y.; Yang, J.; Yang, Y.; Pendharkar, A. I.; Zhang, Y.; Kelmar, S.; Chen, L.; Wu, W.; Zhao, J.; Han, G., Enhancing Photodynamic Therapy through Resonance Energy Transfer Constructed Near-Infrared Photosensitized Nanoparticles. Adv Mater 20一7, 2玖 (28).5. Huang, L.; Zhao, Y.; Zhang, H.; Huang, K.; Yang, J.; Han, G., Expanding Anti-StokesShifting in Triplet-Triplet Annihilation Upconversion for In Vivo Anticancer Prodrug Activation. Angew Chem Int 艾德 Engl 2017, 56 (4陆), 14400-1440四.个人简要介绍:韩纲,University of Massachusetts-Medical School,生化与成员药士学系,副教授。南大化学职业本科和学士,U.S.A.UMASS-Amherst分校化学系获博士学位,劳仑斯伯克利国家实验室分子工厂微米核心博士后。主要在研方向是为:新颖皮米材料的光遗传学神经调节和免疫性工学诊疗以及面向临床转化的风靡分子成像应用,已在Nature, Nat Nanotech, Nat Communications, Elife, PNAS, Nano Letter, ACS Nano, JACS, Angew Chem, Advanced Materials, Small, 等杂志上刊载了80余篇学术诗歌。许多事业被选作宗旨文章,封面作品,或被媒体电视发表。获得5斯特基金会梅尔Carter勒奖、美利哥NIH 尤利卡创新奖、HFSP人类前沿科学项目青年侦查员奖、麻省高校理高校临床与转会科学奖项、亚历克斯s革新奖等。受邀作为U.S.NIH 和国防部(DOD )专家评定核查,脑健康提案评审。担负Nat Mater, Nature Nano, Nano Letter, Angew Chem, JACS, Adv Mater等80余本杂志审阅稿件人。所宣布杂文当前被SCI 期刊引用超过9400次。附属类小部件:无

告诉地点:1陆号楼二楼21四会议室

报告人:钟国富 教育部黑龙江学者特别聘用教师

讲座人:杨鹏宇学士

报告时间

报告人

报告题目

15:00 -16:00

罗正鸿

多尺度反应器工程:从化工传递模型到工业应用

16:00 -17:00

张鹏飞

多相选择性氧化反应中催化剂的控制合成和应用

告诉时间:二零一八年三月1二十一日午后14:00

美国Scripps研商所和肯塔基州生物医药研究所探讨员(Institute Fellow)

招待广大师生踊跃加入!

地点:化行楼226会议室

报告标题:小分子再生文学药物的意识到多肽/乙酰胆碱药物的研究开发

化学与化理高校

图片 1

时间:2016年7月5日中午11点

2017年11月20日

钟国富教授简单介绍:

地点:生科院三楼圆形会议室

报告人简要介绍:

学士,底特律财经大学批注,大学生学士导师,教育部黄河我们特别聘用教授。

杨大学生于201壹年获新加坡共和国国立大学医学大学生学位,时期入眼钻探方向为依照活性的矿物质组深入分析技能在分明活性小分子、天然产物的古生物靶点中的开垦及利用。毕业后进入United StatesScripps研讨所和北卡罗来纳州生物医药商讨所PeterG. Schultz院士的调查切磋组织,从事生物活性小分子,多肽/三磷酸腺苷,抗体药物的钻研和花费,在糖尿病、肥胖、癌症的靶向免疫性医疗领域有深厚的研讨。开采并推断了幸免Hippo 通路的全新小分子化合物,能够用来医治退行性疾病,体内社团和器官原来的地方修复及再生。构建了一种新的“装订”本领平台,并选取于以内源性多肽荷尔蒙的多种长效多肽药物的临床化合物的研究开辟。已在PNAS,Chemistry & Biology,JACS,ANGEW等国际权威性杂志上登载了30 多篇科学杂文,引用次数当先1200次,申请了四项国际发明专利,相关职业被P奥迪Q7Newswire, GlobeNewswire, Bionity,Faculty of 1000等评价。是“Chemistry & Biology”,“ACS Chemical Biology”,“Organic & Biomolecular Chemistry”,“Medicinal Research Review”,“RubiconSC Advances”,“European Journal of Medicinal Chemistry”等20八个期刊的约请审稿人。在2010年获得中中原人民共和国政坛发布的远处留学生奖-国家优质自费留学生奖学金。

罗正鸿:1971出生于吉林泰镜湖区,现为上海浙大特别聘用教授、博士生导师,化学化教院副司长兼化学工业系老板,上海外国语大学化医学科总管。

一玖八〇年七月-1九八3年1月 中国南工业余大学学化学化学工业系 获艺术学大学生学位;1玖八三年8月-壹九8玖年5月 北京华东理法大学 化学系 获历史学大学生学位;198九年五月-19玖5年二月 瑞士联邦辛辛那提大学 有机所获切磋注解(Certificate);19玖五年四月-1997年3月 美利坚合众国斯克利普斯商讨院 获管理学大学生 学位;一玖96年八月-1九九8年1四月 美利哥Scripps探究院 获大学生后 学位。

杨大学生告诉中,将追究小分子再生经济学药物的意识与多肽/抗体药物的开垦平台。在告知的前半有的首要商讨基于Hippo时限信号通路,筛选转录效应因子YAP的小分子激动剂,在成员、细胞及形式动物体内皮肤再生进度的表达。在告知的后半部分,将切磋1种新的“装订”技能平台在内源性多肽荷尔蒙的层层长效多肽药物开拓中的应用。

私家获20壹七年中夏族民共和国化文学会侯德榜化学工业科学技术立异奖、二〇一四年国家杰青及国家科学和技术部中国青年年科学技术创新领军士才。担任法国首都市化学化农学会化学工业业专科高校业委员会副管事人。199伍年、1997和200叁年分别获温尼伯大学、卢萨卡理法大学及四川大学学子、大学生和大学生学位。200三至2011在厦大办事,二零一三年3月开班在上海清华办事现今。

一九八七年十一月-壹玖八八年二月 东京华东理历史学院化学系教授 (Assistant Lecturer);一玖八六年十月-一九八八年三月 东京华东理工业余大学学学化学系助教;一九九伍年11月-19九伍年四月 瑞士联邦阿比让高校化学系教师 (Teaching Assistant);19玖5年1五月-19九六年一月 U.S.Scripps研商院商讨员 (SeniorResearch Associate);19九9年3月-200四年七月 美国Scripps切磋院助理疏解(Assiatant Professor);200伍年5月-200陆年11月 武大大学生物医研院独立PI (Outstanding Principal Investigator);2005年3月-200陆年二月浙大大学化学系,有机所尼罗河招聘录用教授 (Changjiang Professor)、所长 ;200陆年①-201一年7月 新加坡澳大利亚国立高校 化学与生化系副教授 (Associate Professor);二零一三年5月-现今 科伦坡戏剧学院解说。

招待感兴趣的上将同学前来调换。

报告人课题组主要从事高分子化学工业及反应器与化学工业流程工程地点的研究开发工作。课题组的探讨特色为上述反应/反应器的从试验、多规格模拟直至工业应用的系统职业。个人已牵头六项国家资金财产、八陆叁、97三和国家科学技术部首要专属子课题各壹项,若干项集团课题(含陆项援助经费超100万的公司项目)。获5项省部级二等奖(排行第叁)及3项省部级人才奖,以单身报纸发表小编公布国际SCI小说120多篇(含十篇AIChE J.,7篇CES及18篇IEC途胜共3伍篇化学工业3大期刊),担当二本本世界权威国际SCI期刊(Int. J. Chem. React. Eng.和Macromol. React. Eng.)编辑委员会委员或顾问编辑委员会委员以及国内《化管农学报》编辑委员会委员。

致力有机化学、不对称催化和药化等方面包车型大巴研究。

1P.-Y. Yang, H. Zou, E. Chao, L. Sherwood, V. Nunez, M. Keeney, E. Ghartey-Tagoe, Z. Ding, H. Quirino, X. Luo, G. Welzel, G. Chen, P. Singh, A.K. Woods*, P.G. Schultz*, W. Shen* “Engineering a Long-Acting, Potent GLP-1 Analogue for Microstructure-Based Transdermal Delivery” Proc. Natl. Acad. Sci. USA 2016,113, 4140-4145. (In the News: PR Newswire, GlobeNewswire, Bionity)

报告人将从化学工程学科宗旨三传1反角度反映本课题组十伍年来在反应器工程中取得的壹对名堂。爱护出色化学工程职业与任何专门的工作如化学专门的学问的涉嫌以及在骨子里化学工业业生产品制程中的进献。

  1. “Core Structure-Based Design of Organocatalytic [3 2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3 '-Pyrrolidonyl Spirooxindoles”, B. Tan, X. Zeng, W. W. Y. Leong, Z. Shi, C. F. Barbas III,*G. Zhong,**Chem. - Eur. J.*2012,18, 61.

  2. “Chiral Brønsted Acid Catalyzed Enantioselective alpha-Aminoxylation of Enecarbamates”, M. Lu, Y. Lu, D. Zhu, X. Zeng, X. Li,G. Zhong,**Angew. Chem., Int. Ed.*2010,49, 8588.

  3. “Catalytic Asymmetric Formal [4 1] Annulation Leading to Optically Active cis-Isoxazoline N-Oxides”, Z. Shi, B. Tan, W. W. Y. Leong, X. Zeng, M. Lu,G. Zhong,**Org. Lett.*2010,12, 5402.

  4. “Highly Stereoselective Synthesis of Indanes with Four Stereogenic Centers via Sequential Michael Reaction and [3 2] Cycloaddition”, P. J. Chua, B. Tan, L. Yang, X. Zeng, D. Zhu,G. Zhong,**Chem. Commun.*2010,46, 7611.

  5. “Facile Domino Access to Chiral Bicyclo[3.2.1]octanes and Discovery of a New Catalytic Activation Mode”, B. Tan, Y. Lu, X. Zeng, P. J. Chua,G. Zhong,**Org. Lett.*2010,12, 2682.

  6. “Chiral Bronsted Acid Catalyzed Enantioselective Addition of alpha-Isocyanoacetamides to Aldehydes”, X. Zeng, K. Ye, M. Lu, P. J. Chua, B. Tan,G. Zhong,**Org. Lett.*2010,12, 2414.

  7. “Diastereoselective HOTf-catalyzed Three-component One-pot 1,3-Dipolar Cycloaddition of Diazo Ester, Nitrosobenzene and Electron-deficient Alkene”, Z.-J. Xu, D. Zhu, X. Zeng, F. Wang, B. Tan, Y. Hou, Y. Lv,G. Zhong,**Chem. Commun.*2010,46, 2504.

  8. “Water More than Just a Green Solvent: A Stereoselective One-Pot Access to All Chiral Tetrahydronaphthalenes in Aqueous Media”, B. Tan, D. Zhu, L. Zhang, P. J. Chua, X. Zeng,G. Zhong,**Chem. - Eur. J.*2010,16, 3842.

  9. “Organocatalytic Asymmetric Synthesis of Protected alpha,beta-Diamino Acids”, Z. Shi, P. Yu, P. J. Chua,G. Zhong,**Adv. Synth. Catal.*2009,351, 2797.

  10. “Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis”, H. Sun, R. Kong, D. Zhu, M. Lu, Q. Ji, C. W. Liew, J. Lescar,G. Zhong,*Z.-X. Liang,*Chem. Commun.**2009**, 7399.

  11. “Highly Stereoselective One-Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process”, D. Zhu, M. Lu, L. Dai,G. Zhong,**Angew. Chem., Int. Ed.*2009,48, 6089.

  12. “Highly Efficient Asymmetric Trans-Selective Aziridination of Diazoacetamides and N-Boc-imines Catalyzed by Chiral Brønsted Acids”, X. Zeng, X. Zeng, Z. Xu, M. Lu,G. Zhong,**Org. Lett.*2009,11, 3036.

  13. “Chiral Brønsted Acid-Catalyzed Enantioselective alpha-Hydroxylation of beta-Dicarbonyl Compounds”, M. Lu, D. Zhu, Y. Lu, X. Zeng, B. Tan, Z. Xu,G. Zhong,**J. Am. Chem. Soc.*2009,131, 4562.

  14. “Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles”, B. Tan, Z. Shi, P. J. Chua, Y. Li,G. Zhong,**Angew. Chem., Int. Ed.*2009,48, 758.

  15. “Rational Design of Organocatalyst: Highly Stereoselective Michael Addition of Cyclic Ketones to Nitroolefins”, B. Tan, X. Zeng, Y. Lu, P. J. Chua,G. Zhong,**Org. Lett.*2009,11, 1927.

  16. “Recyclable organocatalysis: Highly enantioselective Michael addition of 1,3-diaryl-1,3propanedione to nitroolefins¡”, B. Tan, X. Zhang, P. J. Chua,G. Zhong,**Chem. Commun.*2009, 779.

  17. “An Unexpected N-Heterocyclic Carbene-Catalyzed Annulation of Enals and Nitroso Compounds”, L. Yang, B. Tan, F. Wang,G. Zhong,**J. Org. Chem.*2009,74, 1744.

  18. “Highly enantioselective L-thiaproline catalyzed alpha-aminoxylation of aldehydes in aqueous Media”, P. J. Chua, B. Tan,G. Zhong,**Green Chem.*2009,11, 543.

  19. “Organocatalytic Asymmetric Domino ¦Á-Aminoxylation/Aza-Michael Reactions for the Synthesis of Functionalized Tetrahydro-1,2-oxazines”, M. Lu, D. Zhu, Y. Lu, Y. Hou, B. Tan,G. Zhong,**Angew. Chem., Int. Ed.*2008,47, 10187.

  20. “A Highly Stereoselective Organocatalytic Tandem Aminoxylation/Aza-Michael Reaction for the Synthesis of Tetrahydro-1,2-Oxazines”, D. Zhu, M. Lu, P. J. Chua, B. Tan, F. Wang, X. Yang,G. Zhong,**Org. Lett.*2008,10, 4585.

  21. “A Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Cyclopentanes with Four Chiral Carbons by the Organocatalytic Domino Michael-Henry Reaction”, B. Tan, P. J. Chua, X. Zeng, M. Lu,G. Zhong,**Org. Lett.*2008,10, 3489.

  22. “Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes”, B. Tan, Z. Shi, P. J. Chua,G. Zhong,**Org. Lett.*2008,10, 3425.

  23. “Organocatalytic Asymmetric Tandem Michael-Henry Reactions: A Highly Stereoselective Synthesis of Multifunctionalized Cyclohexanes with Two Quaternary Stereocenters”, B. Tan, P. J. Chua, Y. Li,G. Zhong,**Org. Lett.*2008,10, 2437.

2X. Luo, C. Zambaldo, T. Liu, Y. Zhang, W. Xuan, C.Wang, S.A. Reed, P.-Y. Yang, R.E. Wang, T. Javahishvilli, P.G. Schultz*, T.S. Young* “Recombinant Thiopeptides with Noncanonical Amino Acids” Proc. Natl. Acad. Sci. USA 2016, 113, 3615-3620.

课题组主页:Pelab.sjtu.edu.cn

3Y. Cao, D.T. Rodgers, J. Du, I. Ahmad, E. N. Hampton, J. Ma, M.Mazagova, S. Choi, H. Yun, H. Xiao, P.-Y. Yang, X. Luo, R. Lim, H. Pugh, F. Wang, S.A. Pinkerton, T.M. Wright, C.H. Kim*, P.G. Schultz*, T.S. Young* “Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer” Angew. Chem. Int. Ed.2016, in press.

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